Quadruplet siblings (two boys and two girls) played by Vice Ganda were separated after birth when their grandmother steals two of the siblings (a boy and a girl) away from their mother. The stolen siblings lived a comfortable life in the US, not knowing that their mother and siblings, a gay and a lesbian, struggled to make ends meet in the Philippines. When the boy develops hepatitis that requires him to have a liver transplant from a compatible donor, their father tells them about their siblings in the Philippines, who may be possible candidates as donors. But once the siblings finally meet, pent up resentment and animosity between the girl and the gay siblings, has threatened the chances of the boy sibling’s survival.
Maricel Soriano and Eugene Domingo co-star with Billy Crawford and Andi Eigenmann as lovers set to get married. However, theres one stumbling block: Their mothers (that is, Maricel and Eugene) are against it. The two moms are revealed to be mortal enemies because in their younger years they fell in love with the same man. The young lovers hatch a plan to reconcile their feuding moms. The tragedy: The mothers get lost in a remote island where they are forced to work together and settle their issues if they have to survive. They do become friends again. What they dont know is that their children are on the brink of separation.